Argument: Clinton would cause independents to vote Republican in general election

Issue Report: Clinton vs. Obama

Supporting quotes

Hillary Clinton, to a much greater degree than Obama, reverses these two trends. Independents, given Hillary’s high negative polling, are less likely to vote for her compared to Obama.The right despises her, significantly more so than Obama – making many Republicans vote against her who would have otherwise stayed home.
There are really two things that give the Republicans a chance to win this election: Nominating the most moderate Republican – which they have already done given McCain – and get the most polarizing figure on the Democrat side, making Hillary the most favorable candidate.”